Endocrine Abstracts

Background: Rapid and accurate risk stratification in patients with community-acquired pneumonia (CAP) is an unmet clinical need. Cortisol to DHEA ratio was put forward as a prognostic marker in sepsis. We herein validated the prognostic value of DHEA and DHEAS and of cortisol/DHEA- and cortisol-DHEAS – ratios, respectively, in patients with CAP as the most common (disease resulting) sepsis-defining illness.Methods: We assessed clinical parameters a...

Background: Hyponatremia is highly prevalent in patients with COVID-19. One of the most common causes of hyponatremia in these patients is the syndrome of inadequate antidiuresis (SIAD). Interleukin 6 (IL-6) is a key mediator of inflammation in COVID-19. We hypothesized that hyponatremia in COVID-19 is due to IL-6 mediated non-osmotic arginine vasopressin (AVP) secretion, and that the inverse association between IL-6 and plasma sodium concentration is stronger in COVID-19 comp...

Background: Hyponatremia is common in hospitalized patients and its differential diagnosis and management challenging. An important mechanism is suppressed or adequately or inadequately secreted plasma arginine vasopressin (AVP). Therefore, plasma vasopressin levels may help in the differential diagnosis and in therapy management. Copeptin is secreted in an equimolar ratio to AVP and is more reliable to measure.Methods: In this prospective observational ...

Background: Hyponatremia is the most common electrolyte disturbance in hospitalized patients and associated with a substantial morbidity and mortality. Symptoms of severe hyponatremia vary among patients between nonspecific symptoms such as nausea or malaise or acute life threatening brain oedema. Prospective studies to assess symptoms and mortality in patients with severe hyponatremia are lacking.Methods: In this prospective multicentre observational st...

Introduction: Hyponatremia is the most common electrolyte abnormality in clinical practice and given its impact on mortality and morbidity a relevant medical condition. Nevertheless little is known about factors influencing long-term outcome.Methods: This is a prospective observational 12 months follow-up study of patients with profound hyponatremia (≤125 mmol/l) admitted to the medical emergency department of two tertiary care centers in Switzerla...

Introduction: Systemic glucocorticoid therapy may put patients at risk for later adrenal failure during times of stress, but tapering increases cumulative steroid exposure. We prospectively evaluated adrenal function and clinically relevant hypocortisolism after abruptly stopping prednisone treatment in patients with exacerbated COPD.Methods: This is a pre-specified analysis of the REDUCE randomized trial (Journal of American Medical Association...